-16%
Exemestane 25mg
#1 best sellers in EU 2.
#2 best sellers in EU Warehouse.
Original price was: 113.00$.94.99$Current price is: 94.99$.
d
:
h
:
m
:
s
ACTIVE INGREDIENT: Exemestane 25 mg
TABLET COUNT: 30 COUNTS
ACTIVE HALF-LIFE: 9 HOURS
CLASSIFICATION: ANABOLIC STEROID
DOSAGE MEN: 25-50 MG/DAY
DOSAGE WOMEN: 5-30 MG/DAY
ACNE: RARELY
WATER RETENTION: NO
HBR: NO
HEPATOXITY: LOW
Ship From: Europe
Only 27 left, hurry up.
39 orders in the last 30 days.
Exemestane is a synthetic androgen analogue. It’s is a steroidal inhibitor of aromatase which binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.
Exemestane has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury.
This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Exemestane is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Exemestane decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers. Exemestane is usually not used in women of childbearing age.
Exemestane is usually taken once a day after a meal. Take Exemestane at around the same time every day. You may need to take Exemestane for several years or longer. Continue to take Exemestane even if you feel well. Do not stop taking Exemestane without talking to your doctor.
Effect On Estrogens
Plasma estrogen (estradiol, estrone, and estrone sulfate) suppression is seen starting at a 5-mg daily dose of Exemestane, with a maximum suppression of at least 85% to 95% achieved at a 25-mg dose. Exemestane 25 mg daily reduces whole body aromatization (as measured by injecting radiolabeled androstenedione) by 98% in postmenopausal women with breast cancer. After a single dose of Exemestane 25 mg, the maximal suppression of circulating estrogens occurres 2 to 3 days after dosing and persisted for 4 to 5 days.
Effect On Corticosteroids
In multiple-dose trials of doses up to 200 mg daily, Exemestane selectivity was assessed by examining its effect on adrenal steroids. Exemestane did not affect cortisol or aldosterone secretion at baseline or in response to ACTH at any dose. Thus, no glucocorticoid or mineralocorticoid replacement therapy is necessary with Exemestane treatment.
Other Endocrine Effects
Exemestane does not bind significantly to steroidal receptors, except for a slight affinity for the androgen receptor (0.28% relative to dihydrotestosterone). The binding affinity of its 17dihydrometabolite for the androgen receptor, however, is 100 times that of the parent compound.
Daily doses of Exemestane up to 25 mg had no significant effect on circulating levels of androstenedione, dehydroepiandrosterone sulfate, or 17-hydroxyprogesterone, and were associated with small decreases in circulating levels of testosterone.
Increases in testosterone and androstenedione levels have been observed at daily doses of 200 mg or more. A dose-dependent decrease in sex hormone binding globulin (SHBG) has been observed with daily Exemestane doses of 2.5 mg or higher.
Slight, nondose-dependent increases in serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels have been observed even at low doses as a consequence of feedback at the pituitary level. Exemestane 25 mg daily had no significant effect on thyroid function [free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH).
Absorption
Exemestane is distributed extensively into tissues. Exemestane is 90% bound to plasma proteins and the fraction bound is independent of the total concentration. Albumin and α11-acid glycoprotein both contribute to the binding. The distribution of Exemestane and its metabolites into blood cells is negligible.
Metabolism
Exemestane is extensively metabolized. The initial steps in the metabolism of Exemestane are oxidation of the methylene group in position 6 and reduction of the 17-keto group with subsequent formation of many secondary metabolites.
Each metabolite accounts only for a limited amount of drug-related material. The metabolites are inactive or inhibit aromatase with decreased potency compared with the parent drug. One metabolite may have androgenic activity [see Pharmacodynamics]. Studies using human liver preparations indicate that cytochrome P 450 3A4 (CYP 3A4) is the principal isoenzyme involved in the oxidation of Exemestane. Exemestane is metabolized also by aldoketoreductases.
37 reviews for Exemestane 25mg
Add a review
Related products
-8%
Int'l Warehouse 14
Original price was: 76.00$.70.00$Current price is: 70.00$.
d
:
h
:
m
:
s
-8%
Int'l Warehouse 14
Original price was: 65.00$.60.00$Current price is: 60.00$.
d
:
h
:
m
:
s
-33%
Beligas Pharmaceutical
Original price was: 300.00$.200.00$Current price is: 200.00$.
d
:
h
:
m
:
s
Franklin L. (verified owner) –
Finest Gears is always stocked with what I need for any cycle. Super reliable.
Mason J. (verified owner) –
Best site to order steroids online, hands down.
Damian T. (verified owner) –
My Test levels stayed high and stable throughout my entire cycle.
Dean A. (verified owner) –
No hidden fees, no BS. Just good gear and fast shipping.
Angelo H. (verified owner) –
From beginner to advanced, this shop delivers the kind of results serious lifters are looking for. Trustworthy, consistent, and high quality.
Clyde G. (verified owner) –
The orals don’t hurt my liver or cause issues like others I’ve tried.
Warren S. (verified owner) –
Used their Anavar pre-summer cut — lean, dry, and hard results.
Shaun T. (verified owner) –
My sleep, mood, and lifts all improved. Their gear enhances everything.
Tyrell M. (verified owner) –
I’ve gotten more compliments at the gym since using their gear than ever before.
Rudy P. (verified owner) –
Got a full lab panel done mid-cycle. Bloods confirmed everything is dosed right. Can’t beat that kind of confidence.
Tom A. (verified owner) –
Their EQ and Test C combo gave me that full, pumped look with no bloat. Great for offseason growth.
Marcel G. (verified owner) –
My Test levels stayed high and stable throughout my entire cycle.
Ricky D. (verified owner) –
If you’re serious about your cycle, this is the place to shop. Their products deliver fast results without the side effects I’ve seen from other brands.
Andre B. (verified owner) –
I’ve been using their Test Cyp for the past few weeks, and I can see the difference in my muscle mass and strength. A trusted source for steroids.
Kevin R. (verified owner) –
Bloods confirmed it’s real. Numbers are up and I’m feeling strong. Glad I found these guys.
Chris D. (verified owner) –
Really impressed with the quality of their gear. The testosterone and Tren I’ve used from them has been very effective, and I’ve had no issues.
Tanner Z. (verified owner) –
My body composition changed fast. Lost fat, gained muscle. Exactly what I needed.
Bryce G. (verified owner) –
I don’t leave reviews often, but this company deserves it. Gear is fire, and service is even better.
Xander C. (verified owner) –
Great communication, always a tracking number, and delivery within a few days. Perfect every time.
Kyle H. (verified owner) –
I always get consistent results using Finest Gears. No dips in quality across different batches. That’s rare.
Heath G. (verified owner) –
You can feel the difference by week 2. No guessing — it just works.
Rudy V. (verified owner) –
Just finished a cycle with their Trenbolone and Masteron. Amazing strength gains and fat loss. The products are incredibly effective.
Clyde G. (verified owner) –
Best online source I’ve used, hands down. No pip, no garbage fillers — just legit anabolic steroids.
Ricky D. (verified owner) –
They even include helpful cycle guides and product details. Very professional.
Alton S. (verified owner) –
They even gave me cycle suggestions and support. You don’t get that everywhere.
Troy D. (verified owner) –
I’ve cycled with their EQ, Test E, and Tren mix — unbelievable gains.
Barton K. (verified owner) –
Their customer service actually responds with helpful info. That’s rare in this space. Much respect to these guys.
Dean A. (verified owner) –
Top-notch gear, no side effects, and a legit support team behind it.
Dean A. (verified owner) –
Test E, Tren E, and EQ from them gave me the best size and strength I’ve ever had.
Barry C. (verified owner) –
The clarity and color of the oil tells you it’s clean. Top-level manufacturing.
Scott J. (verified owner) –
Finest Gears is always stocked with what I need for any cycle. Super reliable.
Edgar J. (verified owner) –
My gains have been consistent and side effects minimal, thanks to their clean compounds.
Wallace J. (verified owner) –
Had a small issue with customs once, and they handled it quickly. Professional company.
Cole D. (verified owner) –
They deliver real, high-quality steroids every time. My testosterone levels shot up after using their products. You won’t be disappointed.
Quincy T. (verified owner) –
Just finished a cycle with their Trenbolone and Masteron. Amazing strength gains and fat loss. The products are incredibly effective.
Jeremy G. (verified owner) –
No hidden fees, no BS. Just good gear and fast shipping.
Chase R. (verified owner) –
Never bloated, never shut down too hard. Everything is on point.